On the last day of January, Probe & Drugs ver. 01.2018 was released. In this version of our portal, there is one new compound set and two new filter types.
The one new compound set is the CeMM library of unique drugs (CLOUD) that 'covers prodrugs and active forms at pharmacologically relevant concentrations and is ideally suited for combinatorial studies' (A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor). Our set actually contains only the core 274 compounds (from the original 308 drugs, 34 STEAM drugs with unknown molecular target were excluded).
Concerning the new filter types, one of them is a Reference filter which is able to filter all compounds associated with a reference (i.e., publication, patent, etc.). This filter can be invoked by the filter icon next to a reference in the Targets & Pathways section of each compound, or through the search filed.
The second new filter type is so called special filter. We call it special because normally this type of filter is not available to be used in any database of bioactive compounds. There is currently only one special filter, Number of targets, but there are more to come. This filter is able to filter and sort compounds according to their promiscuity. It can be invoked through the search field or by the filter icon that appears when the mouse cursor is over the number of targets in the Targets & Pathways section. Using this filter, you can for example ask a question "How many approved drugs have more than 50 known targets?".
We hope you’ll find the new data and functionality useful. If you have any suggestions for new functions or compound sets we could include to our database, please, let us know through the contact form.