Earlier today, we released a new version of P&D portal (06.2019) with updated database, integrated set of obsolete compounds, and two new global potency filters.
Concerning new compounds, we updated two of the high-quality probe sets, Open Science Probes and opnMe portal, as well as we integrated the new version of the Guide to Pharmacology database (2019.03). There is also one new commercial set of bioactive compounds from Enamine (Enamine BioReference Compounds) "containing over 2000 compounds with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs and steroids."
We also added a whole new compound set of so-called obsolete/historic compounds (acquired from Chemical Probes.org portal) which we plan to extend in the future. "Compounds in this set are typically non-selective or not sufficiently potent compared with other available chemical probes to merit the probe designation." All compounds contained in this set are marked with a red chemical probe icon (see the picture below).
From this version of P&D, you can already use three special (global) filters based on compounds' promiscuity and potency. Some time ago, we already introduced the Number of targets filter which can used to filter promiscuous compounds, and now we add two new filters concerning their target and cell-based potency: Max potency and Max cell potency filters. Both of these filters take into account all activity data from biochemical/cell-based assays for a single compound and work with its highest values. So, you can, for example, use these filters to get all compounds with less than 5 associated targets with at least 10 nanomolar target and 10 micromolar cell-based potencies.
If you have any suggestions for new functions or compound sets we could include to our database, please, let us know through the contact form.