Compounds
Compound Sets
Custom Sets
Help
News
Login
85
compound sets
127,687
original compounds
112,978
standardized compounds
98,793
nonisomeric compounds
11,767
targets
287,543
compound-target associations
2,815
pathways
6,005
target/pathway classes
515
structural alerts
9,209
matched structural alerts
∞
filter combinations
Probes
&
Drugs
02.2023
COMPOUNDS
APPROVED DRUGS
PROBES
PROBE
TYPES
1,188
experimental
3,670
calculated
1,187
P&D approved
757
high-quality
253
obsolete
178
free of charge
probe
P&D approved
Glucocorticoid receptor
Kinase
similar to Imatinib
nuisance compounds
The Probes & Drugs portal (P&D)
is a hub for the integration of high-quality bioactive compound sets enabling their analysis and comparison. Its main focus is on
chemical probes
and
drugs
but it also includes additional relevant sets from specialist databases/scientific publications, and vendor sets. Upon these, established bioactive chemistry sources (such as
ChEMBL
,
BindingDB
,
Guide To Pharmacology
,
DrugCentral
or
DrugBank
) are utilized for compounds' biological annotation. As of
ver. 02.2023
, the P&D compound database is composed of
85 sources
including
13 probe-related
,
10 drug compilations
,
44 academic/non-commercial sets
and
15 precompiled sets from bioactive compound vendors
.
Guided tour
FAQ
P&D publications
Download
Contact
Examples of complex queries
1
What chemical probes are also approved drugs?
2
Which approved drugs bind to Glucocorticoid and Mineralocrticoid receptor with at least 1 nM potency?
3
What potent GPCR ligands are also potent Kinase ligands?
4
What chemical probes are highly-rated at the Chemical Probes Portal as well as Probes & Drugs?
5
What is the intersection of compounds in DrugBank, DrugCentral and ChEMBL Approved Drugs set?
6
What chemical probes are associated with at least one structural alert (PAINS, nuisance compounds, obsolete structure)?
7
What potent ligands of Estrogen receptor α are dissimilar to Estradiol?
8
What chemical probes are, based on available data, meeting the biochemical potency (100nM) and on target cell-based potency (1µM) criteria?
Latest news
Oct. 9, 2023
P&D 02.2023 is out with probe controls set, highlighted selectivity and target family distribution
The second version of the Probes & Drugs portal this year - 02.2023 - was...
(read more)
April 26, 2023
P&D 01.2023 is out with new datasets, an updated HQCP set and SQLite database
As of today, a new version of the P&D portal (01.2023) is available with two brand...
(read more)
Follow P&D on Twitter
Tweets by #probesanddrugs
LOADING...