Probes
&
Drugs
Compounds
Compound Sets
Custom Sets
Help
News
Login
95
compound sets
162,713
original compounds
145,836
standardized compounds
129,845
nonisomeric compounds
13,571
targets
387,861
compound-target associations
3,026
pathways
25,133
target/pathway classes
535
structural alerts
10,970
matched structural alerts
∞
filter combinations
Probes
&
Drugs
01.2026
COMPOUNDS
APPROVED DRUGS
PROBES
PROBE
TYPES
1,511
experimental
5,424
calculated
1,926
P&D approved
965
high-quality
259
obsolete
236
free of charge
probe
P&D approved
Glucocorticoid receptor
Kinase
similar to Imatinib
nuisance compounds
The Probes & Drugs portal (P&D)
is a hub for the integration of high-quality bioactive compound sets enabling their analysis and comparison. Its main focus is on
chemical probes
and
drugs
but it also includes additional relevant sets from specialist databases/scientific publications, and vendor sets. Upon these, established bioactive chemistry sources (such as
ChEMBL
,
BindingDB
,
Guide To Pharmacology
,
DrugCentral
or
DrugBank
) are utilized for compounds' biological annotation. As of
ver. 01.2026
, the P&D compound database is composed of
95 sources
including
13 probe-related
,
12 drug compilations
,
49 academic/non-commercial sets
and
17 precompiled sets from bioactive compound vendors
.
Guided tour
FAQ
P&D publications
Download
Contact
Examples of complex queries
1
What chemical probes are also approved drugs?
2
Which approved drugs bind to Glucocorticoid and Mineralocrticoid receptor with at least 1 nM potency?
3
What potent GPCR ligands are also potent Kinase ligands?
4
What chemical probes are highly-rated at the Chemical Probes Portal as well as Probes & Drugs?
5
What is the intersection of compounds in DrugBank, DrugCentral and ChEMBL Approved Drugs set?
6
What chemical probes are associated with at least one structural alert (PAINS, nuisance compounds, obsolete structure)?
7
What potent ligands of Estrogen receptor α are dissimilar to Estradiol?
8
What chemical probes are, based on available data, meeting the biochemical potency (100nM) and on target cell-based potency (1µM) criteria?
Latest news
Aug. 13, 2026
P&D 01.2026 released with major data updates and probe labelling refinement
We are excited to announce the release of P&D version 01.2026. This release brings up-to-date...
(read more)
Jan. 21, 2025
P&D 01.2025 is out with a lot of updates and one brand new set of nuisance compounds
The first release of P&D in 2025 is out with all major data sources and...
(read more)
Follow P&D on X (Twitter)
New probes in 01.2026
[[ newCompounds.count ]]
Show all
[[ newCompounds.count ]]
Tweets by #probesanddrugs
LOADING...