General
Preferred name
PHD-1-IN-1
Synonyms
P&D ID
PD167104
CAS
2009343-14-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 ¦ÌM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an "Arg367-out" pocket[1].
PRICE 134
DESCRIPTION PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 ??M).
DESCRIPTION PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM). (TargetMol Bioactive Compound Library)
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-136300
Selleckchem Bioactive Compound Library
phd-1-in-1
TargetMol Bioactive Compound Library
T9627
External IDs
8
Properties
(calculated by RDKit )
Molecular Weight
220.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.27
TPSA
53.98
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PHD1
HIF/HIF Prolyl-Hydroxylase
HIF
Pathway
Chromatin/Epigenetic
Metabolism
Metabolic Enzyme/Protease
Source data