General
Preferred name
PD-1/PD-L1-IN-23
Synonyms
P&D ID
PD166703
CAS
2597056-04-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
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[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].
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[[ compound.targets[tid].gene_name ]]
Compound Sets
1
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
2
Molecular Weight
701.07
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
13
Ring Count
5
Aromatic Ring Count
5
cLogP
6.9
TPSA
115.94
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PD-1/PD-L1
Pathway
Immunology/Inflammation
Source data
