General
Preferred name
Saponarin
Synonyms
P&D ID
PD165996
CAS
20310-89-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-¦ÊB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1¦Â and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders[1][2][3][4][5][6][7].
PRICE 165
DESCRIPTION Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
Compound Sets
2
Cayman Chemical Bioactives
35805
MedChem Express Bioactive Compound Library
HY-N5083
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
594.16
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
10
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
3
cLogP
-2.44
TPSA
260.2
Fraction CSP3
0.44
Chiral centers
10.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
AMPK
COX
Interleukin Related
NF-κB
p38 MAPK
PERK
Pathway
Cell Cycle/DNA Damage
Epigenetics
Immunology/Inflammation
MAPK/ERK Pathway
PI3K/Akt/mTOR
NF-¦ÊB
Source data