General
Preferred name
Procyanidol B4
Synonyms
(-)-Procyanidin B4 ()
P&D ID
PD165841
CAS
29106-51-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
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[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 ¦ÌM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 ¦ÌM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1¦Â and iNOS [1][2].
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Compound Sets
1
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
578.14
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
10
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
4
cLogP
3.0
TPSA
220.76
Fraction CSP3
0.2
Chiral centers
5.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
NF-¦ÊB
Target
Reactive Oxygen Species
COX
Interleukin Related
NO Synthase
Reactive Oxygen Species (ROS)
Source data
