General
Preferred name
Iclepertin
Synonyms
BI-425809 ()
BI 425809 ()
P&D ID
PD165317
CAS
1421936-85-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Iclepertin (BI 425809) is an oral glycine transporter-1 (GlyT1; SLC6A9) inhibitor . Inhibiting GlyT1 increases the extracellular concentration of glycine which is a NMDA receptor co-agonist. This mecahnism is predicted to combat the neural network dysfunction and cognitive impairment that's associated with schizophrenia, and potentially Alzheimer's disease.
(GtoPdb)
DESCRIPTION
Iclepertin, a glycine transporter inhibitor, is an antipsychotic drug.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
8
Molecular Weight
512.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
3.84
TPSA
89.71
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
GlyT
Solubility
Soluble in DMSO
Source data
