General
Preferred name
LSN3318839
Synonyms
LSN-3318839 ()
LSN 3318839 ()
(S, R)-LSN 3318839(Isomer-2764704-18-7) ()
(S, R)-LSN 3318839 ()
P&D ID
PD164450
CAS
2764704-18-7
2765539-92-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The chemical structure and biological activity of LSN3318839 were disclosed in Willard et al. (2021) . LSN3318839 is described as a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP1R). It was used to show that GLP1R potentiation can be used as a mechanism to reduce hyperglycemia.
(GtoPdb)
DESCRIPTION
LSN3318839 is an orally active positive modulator of the glucagon-like peptide-1 receptor (GLP-1R). LSN3318839 can increase the secretion of insulin and has the effect of lowering blood sugar[1].
PRICE
758
PRICE
619
DESCRIPTION
LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.
(TargetMol Bioactive Compound Library)
DESCRIPTION
(S,R)-LSN 3318839 enhances GLP-1R, shows strong blood sugar lowering in animals, works with sitagliptin.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
479.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
4
cLogP
7.08
TPSA
68.01
Fraction CSP3
0.27
Chiral centers
2.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
GCGR
GLP-1
Source data
