General
Preferred name
Remerin
Synonyms
ROEMERINE ()
(-)-Roemerine ()
P&D ID
PD163998
CAS
548-08-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases[1][2][3][4][5].
PRICE 32
DESCRIPTION Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.
Cell lines
1
Organisms
0
Compound Sets
2
Cayman Chemical Bioactives
36035
MedChem Express Bioactive Compound Library
HY-121793
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
279.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
21.7
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
5-HT Receptor
antibiotic
Bacterial
Endogenous Metabolite
iGluR
mGluR
Pathway
Anti-infection
GPCR/G protein
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Source data