General
Preferred name
EM-12
Synonyms
Phthalimidinoglutarimide ()
2-(2,6-Dioxopiperidin-3-yl)phthalimidine ()
EM 12 ()
H_EM12 ()
P&D ID
PD163468
CAS
26581-81-7
103794-93-0
Tags
available
molecular glue
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas[1][2].
PRICE 29
DESCRIPTION 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12 (2-(2,6-Dioxopiperidin-3-yl)phthalimidine)) is a teratogenic Thalidomide analogue that is more active and significantly more stable against hydrolysis than Thalidomide, enhancing 1,2-dimethylhydrazine-induced rat colon adenocarcinomas [1] [2]. (TargetMol Bioactive Compound Library)
Compound Sets
4
MedChem Express Bioactive Compound Library
HY-138793
MolGlueDB
289
ReFrame library
TargetMol Bioactive Compound Library
T41362
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
244.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
1
cLogP
0.45
TPSA
66.48
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
TNF Receptor
Pathway
Apoptosis
Source data