General
Preferred name
DEXOXADROL
Synonyms
DIOXADROL HYDROCHLORIDE ()
DEXOXADROL HYDROCHLORIDE ()
CL-911C ()
Dioxadrol d-form hydrochloride ()
Relane ()
D-dioxadrol hydrochloride ()
U-22559A ()
Dexoxadrol hcl ()
U-22,559A ()
NIH-10375 ()
P&D ID
PD162572
CAS
4741-41-7
631-06-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dioxadrol hydrochloride has been found to be an NMDA antagonist and is used as a dissociative anaesthetic drug. It produces similar effects to PCP in animals. It was developed as analgesics for use in humans, but it was discontinued after patients reported side effects such as nightmares and hallucinations. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
3
BOC Sciences Bioactive Compounds
dioxadrol-hydrochloride-cas-631-06-1-item-476058
ChEMBL Drugs
CHEMBL1165411
CHEMBL3989907
ReFrame library
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
309.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
3.45
TPSA
30.49
Fraction CSP3
0.4
Chiral centers
2.0
Largest ring
6.0
QED
0.94
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Solubility
Soluble in DMSO, not in water
Source data