General
Preferred name
CHIGLITAZAR
Synonyms
CS-038 ()
CARFLOGLITAZAR ()
Carfloglitazar, (s)- ()
CS 038 ()
P&D ID
PD162220
CAS
743438-45-1
Tags
available
drug
Drug indication
Type-2 diabetes
Non-alcoholic steatohepatitis
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chiglitazar (Carfloglitazar) is a PPAR¦Á/¦Ã dual agonist, with EC50s of 1.2, 0.08, 1.7 ¦ÌM for PPAR¦Á, PPAR¦Ã and PPAR¦Ä, respectively.
PRICE 954
DESCRIPTION Chiglitazar is a PPAR ??/??/?? agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus to lower blood glucose, regulate blood lipids, and have anti-inflammatory and anti-fibrotic effects.
DESCRIPTION Chiglitazar (CS-038) is a synthetic small-molecule pan-agonist of peroxisome proliferator-activated receptors (PPARs) α, δ and γ . Structurally this is the S-enantiomer of carfloglitazar (the INN represents the racemic mixture; PubChem CID 9938010). Chiglitazar upregulates the expression of genes downstream of PPARα/δthat are involved in lipid metabolism and thermogenesis. It was developed for potential to treat type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). (GtoPdb)
Compound Sets
6
ChEMBL Drugs
CHEMBL4650349
DrugBank
DB19023
DrugMAP
DM67P0F
Guide to Pharmacology
12287
MedChem Express Bioactive Compound Library
HY-106266
ReFrame library
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
572.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
11
Ring Count
6
Aromatic Ring Count
6
cLogP
7.35
TPSA
80.56
Fraction CSP3
0.11
Chiral centers
1.0
Largest ring
6.0
QED
0.16
Structural alerts
1
anthranil_one_A(38)
c:1:c:c:c:c(:c:1-[#7&!H0;!H1,!$([#7]-[#6]=[#8])])-[#6](-[#6]:[#6])=[#8]
PAINS Family B
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
PPAR
Source data