General
Preferred name
IST5-002
Synonyms
N6-Benzyladenosine-5'-phosphate ()
P&D ID
PD159860
CAS
13484-66-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 ¦ÌM for Stat5a, 3.5 ¦ÌM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML)[1].
PRICE 1520
DESCRIPTION IST5-002 (N6-Benzyladenosine-5'-phosphate) is a selective Stat5a/b inhibitor with anticancer activity that inhibits the transcriptional activity of Stat5a/b and induces apoptosis and death of prostate cancer cells and chronic myelogenous leukemia (CML) cells, which can be used for cancer research.
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-19527
ReFrame library
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
437.11
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
5
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
0.17
TPSA
172.08
Fraction CSP3
0.35
Chiral centers
4.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
STAT
Pathway
JAK/STAT Signaling
Stem Cell/Wnt
Source data