General
Preferred name
DIAPLASININ
Synonyms
PAI-749 ()
PAI749 ()
Diaplasinina ()
Diaplasinine ()
P&D ID
PD159728
CAS
481631-45-2
Tags
available
drug candidate
Drug indication
Thrombosis
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy[1].
PRICE
216
DESCRIPTION
Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
501.25
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
6
Aromatic Ring Count
6
cLogP
7.33
TPSA
68.62
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PAI-1
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
