General
Preferred name
Luteolinidin chloride
Synonyms
Luteolinidin (chloride) ()
P&D ID
PD158874
CAS
1154-78-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 ¦ÌM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 ¦ÌM) and blocks the production of melanin[1][2][3][4][5].
PRICE 256
DESCRIPTION Luteolinidin chloride is a natural product. It is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo. (TargetMol Bioactive Compound Library)
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-129997
TargetMol Bioactive Compound Library
TN1895
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
306.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
0.21
TPSA
92.22
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CD38
NADPH oxidase
Tyrosinase
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data