General
Preferred name
Kaempferol 3-O-sophoroside
Synonyms
Kaempferol 3-O-beta-sophoroside ()
P&D ID
PD158691
CAS
30373-88-7
19895-95-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-¦ÊB expression and the production of TNF-¦Á. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases[1][2][3][4].
PRICE 329
DESCRIPTION Kaempferol 3-O-sophoroside (Kaempferol 3-O-beta-sophoroside) has antibacterial and antiviral activities. (TargetMol Bioactive Compound Library)
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-N2055
Selleckchem Bioactive Compound Library
kaempferol-3-o-sophoroside
TargetMol Bioactive Compound Library
TN1108
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
610.15
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
10
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
-2.42
TPSA
269.43
Fraction CSP3
0.44
Chiral centers
10.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Anti-infection
AMPK
NF-κB
TNF Receptor
Toll-like Receptor (TLR)
TLR2, TLR4
Pathway
Apoptosis
Epigenetics
Immunology/Inflammation
PI3K/Akt/mTOR
Microbiology/virology
NF-¦ÊB
Source data