General
Preferred name
MDK-4025
Synonyms
(2-Chlorophenyl)diphenylmethanol ()
o-Chlorotriphenylmethanol ()
P&D ID
PD158634
CAS
66774-02-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC50 for sI(AHP) inhibition is 1-2 ¦ÌM. (2-chlorophenyl)diphenylmethanol is a weak Ca2+ channel blocker[1].
PRICE 90
DESCRIPTION MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-121914
TargetMol Bioactive Compound Library
T19765
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
294.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
4.62
TPSA
20.23
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Calcium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Source data