General
Preferred name
DMTU
Synonyms
N,N'-Dimethylthiourea ()
P&D ID
PD158360
CAS
534-13-4
61805-96-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (?OH) and blocks ?OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including ?OH scavenging and anti-inflammatory action[1][2].
PRICE 29
DESCRIPTION N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] . (TargetMol Bioactive Compound Library)
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-W027951
Selleckchem Bioactive Compound Library
n-n-dimethylthiourea
TargetMol Bioactive Compound Library
T40615
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
104.04
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.29
TPSA
24.06
Fraction CSP3
0.67
Chiral centers
0.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
antioxidant
Reactive Oxygen Species (ROS)
ROS
Reactive Oxygen Species
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
oxidation-reduction
NF-¦ÊB
Source data