General
Preferred name
Licarin A
Synonyms
(-)-Licarin A ()
(+)-Licarin A ()
LICARINE A ()
P&D ID
PD158082
CAS
51020-86-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-¦Á production (IC50=12.6 ¦ÌM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-¦Á and PGD2 production, and COX-2 expression[1].
PRICE 229
DESCRIPTION Licarin A is a natural anti-inflammatory lignan that inhibiting PKC??/??II and p38 MAPK pathways, thereby decreasing TNF-?? and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.
DESCRIPTION Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression. (TargetMol Bioactive Compound Library)
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-N2252
TargetMol Bioactive Compound Library
T20728
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
326.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.68
TPSA
47.92
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.89
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
p38 MAPK
COX
Prostaglandin Receptor
TNF Receptor
Pathway
Apoptosis
GPCR/G protein
Immunology/Inflammation
MAPK
Source data