General
Preferred name
ALDUMASTAT
Synonyms
(5S)-5-cyclopropyl-5-{3-[(3S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl}imidazolidine-2,4-dione ()
GLPG1972 ()
S201086 ()
G504572 ()
GLPG-1972 ()
G-504572 ()
S-201086 ()
P&D ID
PD157711
CAS
1957278-93-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Osteoarthritis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1].
PRICE
110
DESCRIPTION
Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.
DESCRIPTION
Aldumastat (GLPG1972, S201086) is a clinical lead disease-modifying osteoarthritis agent . It inhibits ADAMTS-5-mediated degradation of the cartilage component aggrecan (AGC). This mechanism is predicted to reduce cartilage degradation in inflammed osteoarthritic joints.
(GtoPdb)
DESCRIPTION
Aldumastat is a potent, seletive and orally active ADAMTS-5 inhibitor, and has 8-fold seletivity over ADAMTS-4. Aldumastat has anticatabolic activity and is used for osteoarthritis research.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
ChEMBL Drugs
DrugBank
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
406.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
1.77
TPSA
81.75
Fraction CSP3
0.55
Chiral centers
2.0
Largest ring
6.0
QED
0.73
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ADAMTS
Pathway
Metabolic Enzyme/Protease
Source data
