General
Preferred name
CA77.1
Synonyms
CA ()
P&D ID
PD157542
CAS
2412270-22-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's disease research[1].
PRICE 58
DESCRIPTION CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD). (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
37300
MedChem Express Bioactive Compound Library
HY-134923
Selleckchem Bioactive Compound Library
ca77-1
TargetMol Bioactive Compound Library
T9062
External IDs
5
Properties
(calculated by RDKit )
Molecular Weight
297.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.91
TPSA
54.88
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Source data