General
Preferred name
sofpironium bromide
Synonyms
BBI4000 ()
BBI 4000 ()
BBI-4000 ()
Sofpironium (bromide) ()
Bromure de sofpironium ()
Sofdra ()
Bromuro de sofpironio ()
P&D ID
PD156848
CAS
1628106-94-4
Tags
available
drug
Drug indication
Primary axillary hyperhidrosis
Hyperhidrosis
Drug Status
approved
Max Phase
4.0
First approval
2024
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes[1].
PRICE 251
DESCRIPTION Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine. (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
38794
ChEMBL Approved Drugs
CHEMBL3707223
ChEMBL Drugs
CHEMBL3707223
DrugMAP
DMPBA0D
MedChem Express Bioactive Compound Library
HY-109013
Selleckchem Bioactive Compound Library
sofpironium-bromide
TargetMol Bioactive Compound Library
T28827
External IDs
8
Properties
(calculated by RDKit )
Molecular Weight
469.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.61
TPSA
72.83
Fraction CSP3
0.64
Chiral centers
3.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
AChR
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data