General
Preferred name
DTAGv-1
Synonyms
dTAGV-1 (TFA) ()
dTAGV-1 (hydrochloride) ()
P&D ID
PD155218
CAS
2624313-15-9
2624313-16-0
Tags
available
probe
PROTAC
Probe info
Probe type
experimental probe
Probe sources
Gray Laboratory Probes
High-quality chemical probes
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
dTAGV-1 TFA is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1]
DESCRIPTION
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
Gray Laboratory Probes
High-quality chemical probes
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
1246.62
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
4
Rotatable Bonds
30
Ring Count
7
Aromatic Ring Count
5
cLogP
9.77
TPSA
242.72
Fraction CSP3
0.51
Chiral centers
7.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FKBP12
FKBP12F36V
FKBP1A
FKBP
PROTACs
Pathway
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Immunology/Inflammation
Source data
