General
Preferred name
BI-4924
Synonyms
P&D ID
PD155017
CAS
2244452-09-1
Tags
free of charge
available
probe
Probe info
Probe type
experimental probe
Probe sources
High-quality chemical probes
opnMe Portal
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].
PRICE 1670
DESCRIPTION BI-4924 is a selective and potent inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM) that disrupts serine biosynthesis by intracellular trapping, and can be used in the study of diseases caused by dysfunction.
DESCRIPTION BI-4924 is a highly potent inhibitor of PHGDH with good selectivity. We also provide the cell permeable prodrug BI-4916 which is the ethyl ester of BI-4924 and was used to achieve intracellular enrichment of BI-4924. In addition, we provide the negative control BI-5583. (opnMe Portal)
Compound Sets
4
CZ-OPENSCREEN Bioactive Library
High-quality chemical probes
PD155017
MedChem Express Bioactive Compound Library
HY-126254
opnMe Portal
phgdh-inhibitor-bi-4924
External IDs
8
Properties
(calculated by RDKit )
Molecular Weight
498.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
3.12
TPSA
125.7
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Phosphoglycerate Dehydrogenase (PHGDH)
PHGDH
Pathway
Metabolic Enzyme/Protease
Source data