General
Preferred name
pociredir
Synonyms
Pociredir (hydrochloride) ()
FTX-6058 ()
FTX-6058 (hydrochloride) ()
P&D ID
PD154872
CAS
2490676-18-9
2490676-19-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
sickle cell anemia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FTX-6058 binds to embryonic ectoderm development (EED) and induces foetal haemoglobin (HbF) tetramer production via modulation of PRC2. It was developed by Fulcrum Therapeutics as an oral drug for the treatment of sickle cell disease or beta thalassemia. We matched the chemical structure for the INN 'pociredir' (from the WHO's proposed INN list 127, July 2022) to the structure for FTX-6058. (GtoPdb)
DESCRIPTION Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and ¦Â-thalassemia[1][2].
DESCRIPTION Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and ¦Â-thalassemia[1][2].
Compound Sets
3
ChEMBL Drugs
CHEMBL6067682
Guide to Pharmacology
11523
MedChem Express Bioactive Compound Library
HY-139400
HY-139400A
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
403.14
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
4
cLogP
3.72
TPSA
73.57
Fraction CSP3
0.23
Chiral centers
1.0
Largest ring
9.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histone methyltransferase
Pathway
Epigenetics
Source data