General
Preferred name
OPIORPHIN
Synonyms
P&D ID
PD154858
CAS
864084-88-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 ¦ÌM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].
DESCRIPTION Opiorphin is an endogenous pentapeptide. It reduces the breakdown of the natural analgesic enkephalins by acting as an inhibitor of enkephalin-degrading proteases including neutral ecto-endopeptidase (MME; neprilysin), ecto-aminopeptidase N (ANPEP; ANP) and dipeptidyl peptidase DPP3. (GtoPdb)
Compound Sets
2
Guide to Pharmacology
11538
MedChem Express Bioactive Compound Library
HY-W345510
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
692.37
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
12
Rotatable Bonds
23
Ring Count
1
Aromatic Ring Count
1
cLogP
-5.05
TPSA
371.84
Fraction CSP3
0.52
Chiral centers
5.0
Largest ring
6.0
QED
0.03
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Neprilysin
Pathway
Metabolic Enzyme/Protease
Source data