General
Preferred name
Isobavachromene
Synonyms
4-Hydroxylonchocarpin ()
P&D ID
PD148833
CAS
56083-03-5
52801-22-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isobavachromene is an antibacterial agent[1].
DESCRIPTION 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities[1].
PRICE 147
PRICE 286
DESCRIPTION 4-Hydroxylonchocarpin is a natural product from Psoralea corylifolia
DESCRIPTION Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
2
Compound Sets
4
DrugMAP
DM36PHM
MedChem Express Bioactive Compound Library
HY-N2208
HY-N2208A
Other bioactive compounds
TargetMol Bioactive Compound Library
TN1774
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
322.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.18
TPSA
66.76
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Bacterial
Ornithine decarboxylase
p38 MAPK
Pathway
Microbiology/virology
MAPK/ERK Pathway
Anti-infection
Source data