General
Preferred name
GFB-8438
Synonyms
GFB-8438 ()
P&D ID
PD144417
CAS
2304549-73-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 ¦ÌM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].
PRICE 62
DESCRIPTION GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 ??M of hTRPC5 and hTRPC4, respectively).
DESCRIPTION GFB-8438 is a selective TRPC5 channel blocker . (GtoPdb)
DESCRIPTION GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). (TargetMol Bioactive Compound Library)
Compound Sets
6
Cayman Chemical Bioactives
43035
Concise Guide to Pharmacology 2023/24
12527
Guide to Pharmacology
12527
MedChem Express Bioactive Compound Library
HY-133012
Selleckchem Bioactive Compound Library
gfb-8438
TargetMol Bioactive Compound Library
T11394
External IDs
9
Properties
(calculated by RDKit )
Molecular Weight
386.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
2.29
TPSA
69.3
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
TRP Channel
TRPC5
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data