General
Preferred name
Activated charcoal
Synonyms
CHARCOAL, ACTIVATED ()
Charcoal ()
Carbon, medicinal ()
Medicinal charcoal ()
Carbon ()
Carbo vegetabilis ()
AST-120 ()
Medicinal carbon ()
Ast 120 ()
P&D ID
PD143905
CAS
1333-86-4
Tags
drug
Drug Status
investigational
approved
Max Phase
Phase 3
Drug indication
Antidote (general purpose)
Pharmaceutic Aid (adsorbant)
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Active charcoal acts by binding to the pharmaceutical drugs or poisons such as organophosphates and decreasing the systemic absorption of toxic agents. Molecules with large volume of distribution, thus likely having higher lipid solubility, tends to bind have better absorptive binding to activated charcoal. Following the administration of activated charcoal, cathartics are indicated to evacuate the charcoal-poison bonded complex from the gastrointestinal tract. ; Activated charcoal may also have an effect on systemic drug levels by lowering the serum levels of already absorbed drugs or toxins. Many absorbed drugs that undergo significant hepatic metabolism and conjugation are eliminated via bile into the small intestines. When they reach the small intestines, drug conjugates can undergo hydrolysis and return to the enterohepatic circulation. Activated charcoal interferes with this process and binds to the conjugated drug before hydrolysis or the free deconjugated drug before reabsorption.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
Other bioactive compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
12.0
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
0.08
TPSA
0.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.35
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
