General
Preferred name
PF-06882961
Synonyms
DANUGLIPRON ()
UNII-2HJV78O0SS ()
Danuglipron (PF-06882961) ()
PF-06882961 Tris ()
DANUGLIPRON TROMETHAMINE ()
PF-06882961-82 ()
PF-06882961 tromethamine ()
P&D ID
PD143766
CAS
2230198-02-2
2230198-03-3
Tags
available
drug candidate
Drug indication
Type 2 diabetes
Obesity
Drug Status
investigational
Max Phase
2.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Danuglipron (PF-06882961) is a small molecule, non-peptide, orally active agonist of the human (and monkey) glucagon-like peptide-1 receptor (GLP-1R) . It was developed as a once-daily pill alternative to established peptide GLP-1R agonists that are used to treat diabetes, and in some instances, obesity (e.g. and ). (GtoPdb)
DESCRIPTION Danuglipron (PF-06882961) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron has the potential for type 2 diabetes research[1][2].
PRICE 161
PRICE 522
DESCRIPTION PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist. (TargetMol Bioactive Compound Library)
DESCRIPTION PF-06882961 Tris (UNII-2HJV78O0SS) is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL4518483
CHEMBL4650218
DrugBank
DB16043
DrugMAP
DM7EJ8S
Guide to Pharmacology
12064
MedChem Express Bioactive Compound Library
HY-125824
Selleckchem Bioactive Compound Library
pf-06882961
TargetMol Bioactive Compound Library
T12431
T8876
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
555.23
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
6
Aromatic Ring Count
4
cLogP
4.89
TPSA
113.5
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
GCGR
Glucagon Receptor
GLP-1
Source data