General
Preferred name
TAK-653
Synonyms
Osavampator ()
NBI-1065845 ()
TAK-653 ()
P&D ID
PD143659
CAS
1358751-06-0
Tags
available
drug candidate
Drug indication
depressive disorder
Depression
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 ¦ÌM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].
PRICE 75
DESCRIPTION TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models. (TargetMol Bioactive Compound Library)
Compound Sets
6
Cayman Chemical Bioactives
42187
ChEMBL Drugs
CHEMBL4594403
DrugBank
DB16304
DrugMAP
DMNB4P1
MedChem Express Bioactive Compound Library
HY-115864
TargetMol Bioactive Compound Library
T61518
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
373.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
3.11
TPSA
71.33
Fraction CSP3
0.47
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
iGluR
Lipoxygenase
AMPAR
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data