General
Preferred name
TEGOPRAZAN
Synonyms
RQ-4 ()
CJ-12420 ()
RQ-00000004 ()
CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004 ()
LXI-15028 ()
P&D ID
PD143531
CAS
942195-55-3
Tags
available
drug
Drug Status
investigational
approved
Max Phase
3.0
Drug indication
Helicobacter pylori infectious disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a reversible, orally active and highly selective inhibitor of gastric H+/K+-ATPase. Tegoprazan inhibits gastric acid secretion and motility against porcine, canine and human H+/K+-ATPase with IC50 values ranging from 0.29-0.52 ¦ÌM in vitro. Tegoprazan significantly improves colitis and enhances the intestinal epithelial barrier function in mice. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3].
PRICE 159
DESCRIPTION Tegoprazan is an orally active, highly selective gastric H+/K+-ATPase inhibitor that controls gastric acid secretion and motility, with an IC50 of 0.29-0.52 ??M for porcine, canine, and human H+/K+-ATPase in vitro.
DESCRIPTION Tegoprazan (CJ-12420) is an oral, fast-acting potassium-competitive acid blocker (P-CAB) . It reduces gastric acid secretion by inhibiting the H+/K+ transporter (ATP4A; a.k.a. the gastric proton pump) in the stomach lining. (GtoPdb)
DESCRIPTION Tegoprazan is an orally active, highly selective gastric H+/K+-ATPase inhibitor that controls gastric acid secretion and motility, with an IC50 of 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPase in vitro. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
33243
ChEMBL Drugs
CHEMBL4297583
DrugBank
DB16690
Guide to Pharmacology
12008
MedChem Express Bioactive Compound Library
HY-17623
ReFrame library
Selleckchem Bioactive Compound Library
tegoprazan
TargetMol Bioactive Compound Library
T17030
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
387.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.75
TPSA
67.45
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
H+/K+-ATPase
Proton Pump
Na+/K+ ATPase
Potassium Channel
ATPase
Pathway
Membrane Transporter/Ion Channel
Source data