General
Preferred name
BSJ-02-162
Synonyms
CDK4/6-IN-11 ()
P&D ID
PD142095
CAS
2139329-47-6
Tags
PROTAC
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader[1]. CDK4/6-IN-11 consists of a thalidomide-based E3 ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717), a target protein ligand (red part) Palbociclib (HY-50767), and a PROTAC linker (black part) Boc-NH-C4-Br (HY-W007803). E3 ligase ligand and linker can form Thalidomide-NH-amido-C4-Br (HY-170307).
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[[ compound.targets[tid].gene_name ]]
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free of charge
External IDs
7
Molecular Weight
831.38
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
4
Rotatable Bonds
14
Ring Count
8
Aromatic Ring Count
4
cLogP
3.09
TPSA
220.93
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.08
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CDK
PROTACs
CDK4
CDK6
Pathway
Cell Cycle/DNA Damage
Source data
