General
Preferred name
IM-156 FREE BASE
Synonyms
Lixumistat (hydrochloride) ()
Lixumistat (acetate) ()
HL271 ()
IM156 (hydrochloride) ()
HL156A (hydrochloride) ()
IM156 ()
HL156A ()
HL271 (acetate) ()
LIXUMISTAT ACETATE ()
LIXUMISTAT ()
HL156A FREE BASE ()
IM156 FREE BASE ()
HL-156A FREE BASE ()
HL271 ACETATE ()
IM-156 ()
HL-156A ()
IM-156 (acetate) ()
IM-156 acetate ()
P&D ID
PD134064
CAS
1422365-52-3
1422365-94-3
1422365-93-2
2043654-54-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
1.0
Drug indication
Neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
88
DESCRIPTION
IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3].
DESCRIPTION
Lixumistat (IM156; HL156A; HL271) acetate, a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. Lixumistat (acetate) attenuates aging-associated cognitive impairment in animal model[1][2]. Lixumistat (acetate) is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors[3].
PRICE
400
DESCRIPTION
IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 ??M) and AMP-activated protein kinase alpha (AMPK??), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPK?? activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats .
DESCRIPTION
Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model[1][2]. Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors[3].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
315.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
2.55
TPSA
84.23
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AMPK
Oxidative Phosphorylation
AMPK,Apoptosis related,OXPHOS
Pathway
Epigenetics
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Source data
