General
Preferred name
vimseltinib
Synonyms
DCC-3014 ()
DP-6865 ()
P&D ID
PD133944
CAS
1628606-05-2
Tags
available
probe
drug
Drug indication
Neoplasm
Solid tumour/cancer
Drug Status
approved
investigational
Max Phase
3.0
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 ¦ÌM and 0.1-1 ¦ÌM, respectively[1].
PRICE 292
DESCRIPTION Vimseltinib (DCC-3014) is a dual inhibitor targeting c-FMS (CSF-IR) and c-Kit with IC50 values of less than 0.01 ??M and 0.1-1 ??M, respectively.
DESCRIPTION The chemical structure submitted to the WHO for the INN vimseltinib is identical to that of the investigational, oral CSF1R inhibitor DCC-3014, via a PubChem structure match. The compound is claimed as example 10 in Deciphera Pharmaceuticals' patent WO2014145025A2, in which KIT proto-oncogene inhibitory activity is also noted . Name to structure was formally disclosed in Caldwell et al. (2022) . Vimseltinib's selectivity is determined by its interactions within the switch control region of the CSF1R that regulates kinase conformational activation. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION Vimseltinib (DCC-3014) is a dual inhibitor targeting c-FMS (CSF-IR) and c-Kit with IC50 values of less than 0.01 μM and 0.1-1 μM, respectively. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
13
Cayman Chemical Bioactives
38783
ChEMBL Drugs
CHEMBL5095202
Chemical Probes.org
vimseltinib
CZ-OPENSCREEN Bioactive Library
DrugBank
DB17520
DrugMAP
DMHW289
EUbOPEN Chemogenomics Library
EUB0002348
Guide to Pharmacology
11190
High-quality chemical probes
PD133944
MedChem Express Bioactive Compound Library
HY-136256
PKIDB
Selleckchem Bioactive Compound Library
vimseltinib
TargetMol Bioactive Compound Library
T10652
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
431.21
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
3.56
TPSA
99.75
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
c-Fms
c-Kit
CSF-1R
c-Kit,CSF-1R
CSF1R
Pathway
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target class
Kinase
Target subclass
TK
Recommended Cell Concentration
None
Source data