General
Preferred name
ZABOFLOXACIN
Synonyms
Zabofloxacin (hydrochloride) ()
DW-224a ()
P&D ID
PD131899
CAS
219680-11-2
623574-00-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zabofloxacin is a fluoroquinolone antibacterial that inhibits type II and type IV topoisomerases . It has activity against Gram-positive bacteria and against Gram-negative Neisseria gonorrhoeae, including strains that are resistant to other quinolone antibacterials. (GtoPdb)
DESCRIPTION Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1].
Compound Sets
2
Guide to Pharmacology
10873
MedChem Express Bioactive Compound Library
HY-106410A
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
401.15
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
0.98
TPSA
109.05
Fraction CSP3
0.47
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Topoisomerase
Pathway
Anti-infection
Cell Cycle/DNA Damage
Source data