General
Preferred name
JBSNF-000088
Synonyms
JBSNF000088 ()
6-Methoxynicotinamide ()
P&D ID
PD131490
CAS
7150-23-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 ¦ÌM, 2.8 ¦ÌM, and 5.0?¦ÌM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease[1].
PRICE 29
DESCRIPTION JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
29920
MedChem Express Bioactive Compound Library
HY-112584
Selleckchem Bioactive Compound Library
jbsnf-000088
TargetMol Bioactive Compound Library
T8106
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
152.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.19
TPSA
65.21
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
NNMT
Source data