General
Preferred name
MLT-231
Synonyms
P&D ID
PD128819
CAS
2682102-10-7
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse[1].
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[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
2
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
6
Molecular Weight
469.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
4.05
TPSA
96.68
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
MALT protein 1 inhibitor
Target
MALT1
Pathway
Metabolic Enzyme/Protease
NF-κB
NF-¦ÊB
Source data
