General
Preferred name
SIMUFILAM
Synonyms
PTI-125 dihydrochloride ()
PTI-125 ()
Simufilam (hydrochloride) ()
PTI-125 (hydrochloride) ()
Simufilam dihydrochloride ()
SIMUFILAM HYDROCHLORIDE ()
Filora ()
PTI-910 ()
C0105 ()
C-0105 ()
C0105M ()
PTI-125 DIHYDROCHLORIDE MONOHYDRATE ()
PTI-910 DIHYDROCHLORIDE MONOHYDRATE ()
PTI-910 hydrochloride ()
PTI-125 hydrochloride ()
P&D ID
PD128126
CAS
1224591-33-6
2480226-07-9
2480226-06-8
Tags
available
drug candidate
Drug indication
Alzheimer disease
Neoplasm
Drug Status
investigational
Max Phase
1.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Simufilam (PTI-125) hydrochloride, a compound, can be uesd for screening of agent candidate.
PRICE
182
DESCRIPTION
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its ??7nAChR/TLR4 associations and downstream pathologies.
DESCRIPTION
Simufilam is a filamin A altered conformations binder.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
259.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
1.04
TPSA
35.58
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
a7nAChR
Amyloid-β
iGluR
MTOR
Tau Protein
Actin
Beta Amyloid
Member status
member
MOA
Filamin A modulator
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
PI3K/Akt/mTOR
Source data
