General
Preferred name
vamifeport
Synonyms
VIT-2763 ()
VAMIFEPORT HYDROCHLORIDE ()
VIT- 2763-PM1 ()
VIT-2763-PM1 ()
Vamifeport trihydrochloride ()
VIT-2763-PM1 TRIHYDROCHLORIDE ()
VIT-2763 trihydrochloride ()
VIT-2763 3HCl ()
P&D ID
PD127906
CAS
2095668-10-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
2.0
Drug indication
iron metabolism disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vamifeport (VIT-2763) is a first in-class, orally administered small molecule inhibitor of ferroportin (SLC40A1) . It was developed by Vifor Pharma for the prevention of iron overload and to treat β-thalassaemia. (GtoPdb)
DESCRIPTION VIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of ¦Â-thalassemia[1].
PRICE 394
DESCRIPTION Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in ??-thalassemia.
DESCRIPTION Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia. (TargetMol Bioactive Compound Library)
Compound Sets
5
ChEMBL Drugs
CHEMBL4596566
CHEMBL4475199
DrugBank
DB17692
Guide to Pharmacology
11183
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T39520
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
408.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
4
cLogP
2.39
TPSA
108.73
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Ferroptosis
Ferroportin
Member status
member
MOA
Ferroportin inhibitor
Pathway
Apoptosis
Membrane Transporter/Ion Channel
Source data