General
Preferred name
Rheb inhibitor NR1
Synonyms
P&D ID
PD127524
CAS
2216763-38-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 ¦ÌM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1].;(Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
PRICE 362
DESCRIPTION Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
43360
MedChem Express Bioactive Compound Library
HY-124798
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T16741
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
575.97
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
7.31
TPSA
62.54
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.26
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Member status
member
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
MTOR
mTORC1
Source data