General
Preferred name
CENTANAFADINE HYDROCHLORIDE
Synonyms
EB-1020 hydrochloride ()
Centanafadine (hydrochloride) ()
EB-1020 (hydrochloride) ()
DOV-216419 HYDROCHLORIDE ()
DOV 216,419 HYDROCHLORIDE ()
DOV 216,419 ()
EB-1020 ()
P&D ID
PD127415
CAS
923981-14-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Attention deficit hyperactivity disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
PRICE
126
DESCRIPTION
Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
ChEMBL Drugs
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
8
Molecular Weight
245.1
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
3.12
TPSA
12.03
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
Adrenergic Receptor
Dopamine Transporter
Serotonin Transporter
dopamine
Norepinephrine (NE)
serotonin
Source data
