General
Preferred name
AFOXOLANER
Synonyms
NexGard ()
AH252723 ()
A1443 ()
Nexgard spectra conponent afoxolaner ()
Frontpro (previously known as afoxolaner merial) ()
P&D ID
PD127412
CAS
1093861-60-9
Tags
available
drug
Approved by
FDA
Drug Status
vet_approved
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect ¦Ã-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
PRICE 70
DESCRIPTION Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
33317
ChEMBL Drugs
CHEMBL2219412
DrugBank
DB11369
DrugBank Approved Drugs
DB11369
DrugCentral
5660
MedChem Express Bioactive Compound Library
HY-16974
Selleckchem Bioactive Compound Library
afoxolaner
TargetMol Bioactive Compound Library
T13536
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
625.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
6.5
TPSA
79.79
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Chloride channel
GABA
GABA Receptor
Parasite
Pathway
Membrane Transporter/Ion Channel
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Source data