General
Preferred name
KUSHENOL A
Synonyms
Leachianone E ()
P&D ID
PD127293
CAS
99217-63-7
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 ¦ÌM and 0.4 ¦ÌM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 ¦ÌM; Ki: 6.8 ¦ÌM) and ¦Â-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
Compound Sets
2
DrugMAP
DMCFHPD
MedChem Express Bioactive Compound Library
HY-N2278
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
408.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
5.6
TPSA
86.99
Fraction CSP3
0.32
Chiral centers
2.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Glycosidase
Tyrosinase
Pathway
Metabolic Enzyme/Protease
Source data