General
Preferred name
JR14a
Synonyms
5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride ()
P&D ID
PD127055
CAS
2411440-41-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation[1].
PRICE 322
DESCRIPTION JR14a is reported as an antagonist of the Complement C3a receptor (C3aR) . It is orally active, and elicits anti-inflammatory effects in vitro and in vivo. It is a more potent antagonist than . (GtoPdb)
DESCRIPTION JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. (TargetMol Bioactive Compound Library)
Compound Sets
6
Concise Guide to Pharmacology 2021/22
10595
Concise Guide to Pharmacology 2023/24
10595
Guide to Pharmacology
10595
MedChem Express Bioactive Compound Library
HY-138161
Selleckchem Bioactive Compound Library
jr14a
TargetMol Bioactive Compound Library
T9316
External IDs
9
Properties
(calculated by RDKit )
Molecular Weight
532.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
5
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
3
cLogP
4.99
TPSA
128.3
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Target
Complement System
C3a
Source data