General
Preferred name
Triazavirin
Synonyms
7-methylsulfanyl-3-nitro-6H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-4-one ()
Riamilovir ()
TZV, Riamilovir ()
TRIAZAVIRINE ()
P&D ID
PD126861
CAS
928659-17-0
123606-06-4
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Riamilovir is a synthetic guanine derivative that acts as a broad-spectrum antiviral agent. It disrupts viral transcription and replication, with antiviral activity against a range of RNA viruses. The exact molecular target has not been reported, although molecular docking studies suggest an interaction of riamilovir with SARS-CoV-2 Mpro (3CL protease) . Consequently, riamilovir has been advanced into clinical evaluation for potential anti-SARS-CoV-2 activity.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
6
Cayman Chemical Bioactives
DrugBank
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
228.01
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.56
TPSA
119.08
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Microbiology&virology
Immunology/Inflammation
Anti-infection
Cell Cycle/DNA Damage
Target
Nucleoside Analogue
Influenza Virus
Antiviral
DNA/RNA Synthesis
Nucleoside antimetabolite/analog
DNA/RNA Synthesis,Influenza Virus,Nucleoside Analog/Antimetabolite
Antiviral,COVID-19,SARS-CoV
Source data
