General
Preferred name
Dotinurad
Synonyms
(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone ()
FYU-981 ()
P&D ID
PD126294
CAS
1285572-51-1
Tags
available
drug
Approved by
PMDA
First approval
2020
Drug Status
investigational
approved
Max Phase
3.0
Drug indication
hyperuricemia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 397
DESCRIPTION Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 ??M for uric acid).
DESCRIPTION Dotinurad, a novel selective urate reabsorption inhibitor (SURI), that acts on the URAT-1 transporter. (GtoPdb)
DESCRIPTION Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid). (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A19354
Cayman Chemical Bioactives
41014
ChEMBL Drugs
CHEMBL4594446
Concise Guide to Pharmacology 2021/22
11389
Concise Guide to Pharmacology 2023/24
11389
DrugBank
DB16145
DrugCentral
5425
DrugCentral Approved Drugs
5425
Guide to Pharmacology
11389
Selleckchem Bioactive Compound Library
dotinurad
TargetMol Bioactive Compound Library
T15160
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
356.96
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.09
TPSA
74.68
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
URAT1
OAT
Pathway
Membrane Transporter/Ion Channel
Source data