General
Preferred name
PLX5622
Synonyms
PLX-5622 ()
PLX5622 (hemifumarate) ()
PLX5622 in AIN-76A Diet (1200 ppm) ()
PLX5622 (hemifumarate) ()
P&D ID
PD126198
CAS
1303420-67-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Rheumatoid arthritis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ¦ÌM; Ki=5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 hemifumarate demonstrates desirable PK properties in varies animals[1][2].
DESCRIPTION PLX5622 is an orally available and highly selective kinase inhibitor targeting CSF1R (FMS) kinase and other Type III receptor tyrosine kinases. It is being investigated for its anti-inflammatory effects in autoimmune diseases, in the first instance rheumatoid arthritis (RA). (GtoPdb)
DESCRIPTION PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ¦ÌM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1][2].
PRICE 134
DESCRIPTION PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
9
AdooQ Bioactive Compound Library
A18888
Axon Medchem Screening Library
3054
Cayman Chemical Bioactives
28927
36277
ChEMBL Drugs
CHEMBL3639728
EUbOPEN Chemogenomics Library
EUB0000697
Guide to Pharmacology
9105
MedChem Express Bioactive Compound Library
HY-114153A
HY-114153
HY-114153C
Selleckchem Bioactive Compound Library
plx5622
TargetMol Bioactive Compound Library
T7100
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
395.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
4.15
TPSA
75.72
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
c-Fms
CSF-1R
CSF1R inhibitor
Pathway
Protein Tyrosine Kinase/RTK
Tyrosine Kinase/Adaptors
Recommended Cell Concentration
1 uM
Source data