General
Preferred name
CB-6644
Synonyms
P&D ID
PD126188
CAS
2316817-88-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1].
PRICE 870
DESCRIPTION CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1]. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
4
AdooQ Bioactive Compound Library
A19157
Cayman Chemical Bioactives
36125
MedChem Express Bioactive Compound Library
HY-114429
TargetMol Bioactive Compound Library
T10693
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
572.22
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
3
cLogP
4.71
TPSA
103.59
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
7.0
QED
0.37
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
RUVBL1/2
DNA/RNA Synthesis
Pathway
Cell Cycle/DNA Damage
Source data